Loss of interferon regulatory factor 1 and PAX6 induced by FOXC1 dysfunction is linked to the corneal ulcer. FOXC1 depletion not only activates the keratinization pathway and reprograms corneal epithelial cells into skin-like epithelial cells, but also disrupts the collagen metabolic process and interferon signaling pathways. FOXC1 governs the fate of the corneal epithelium by directly binding to lineage-specific open promoters or enhancers marked by H3K4me2. Deficiency of FOXC1 and alternation in epithelial features occur in patients with corneal ulcers. Here, we find that FOXC1 and paired box 6 (PAX6) are co-expressed in the human limbus and central corneal epithelium. Thanks, I will look at the videos again.Forkhead box C1 (FOXC1) is required for neural crest and ocular development, and mutations in FOXC1 lead to inherited Axenfeld–Rieger syndrome. When it seemed like I might just be crossthreading I backed off. To do that is difficult enough, but you can't see the bolt at all it is a flathead (so it's more difficult to screw in than a Phillips) and the bolt has something like 6 inches of threading each turn of which is very very tight. The real issue being that to set the bolt into its grooves, one must seemingly push the bellows back up into the frame of the organ, and thread the bolt into place. There's a back panel that I haven't been able to get back on because in the process of trying to repair it (which I eventually did but didn't have to do this step) I took out a flathead bolt that ran from the very back of the organ, visible only via a tiny hole with a flap over it (basically invisible without heavy-duty flashlights, and even then barely visible), without which being in there, the entire bellows mechanism hangs out the rear end just enough so that the rear panels no longer fit on it anymore. Take a few days off, rent a U-Haul trailer and enjoy a little road trip delivering it! If you get $100, consider yourself lucky! Alternatively, you could contact the Museum and see if they can put you in contact with a restorer who's interested in it for parts or as a project. As for what to do with it next: anything but junking it! If you find you can't keep it or don't want it any more, you could try selling on Craigslist or Ebay. If it's really not your thing, you can just enjoy making music on whatever parts of the thing do actually work. If you like tinkering and have a bit of a MacGyver attitude towards fixing things, than this can be an enjoyable hobby. Is it worth it? That's really a question only you can answer. Those are fairly easy fixes! Just get on the Youtube and look up "estey organ restoration" and you'll find loads of interesting videos that will help you on the way. Or maybe some dust has gotten into a reed and it no longer plays. It could be that some linkage has gotten loose or out of alignment. If you're anywhere close to New England, you might consider a visit.Īs for how well it plays: it plays well because it was built well! Things were built to last in those days and very many of these instruments have survived into the present.Īs for fixing it, if you have any skill with tools at all, you should be able remove the top and any access panels to assess what might be wrong with the stops (those knobs) that aren't working. You can find all kinds of resources there. But there is one part of the factory that houses the Estey Organ Museum. What is interesting about the company is that most of its buildings still exist and have been repurposed into shops and living spaces. These instruments were very popular, not only in small churches, but also homes, schools, and in public places. Estey was but one of a dozen or more well known organ & piano makers active at that time. You can often find parts on Ebay, for example. That doesn't mean you can't get parts if you're really interested in tackling a restoration project. Basically, right now it's worth $70, because that's what you were willing to pay for it.Īs for the company, yeah, the guy was either lying outright or sadly misinformed. First off, you got a very good deal! Prices are so variable on these things that it's really almost impossible to say how much it's worth.